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Tuesday, September 16, 2008

Gene fuels deadly prostate cancer - BBC News

A faulty factor closely associated with breast malignant neoplastic disease is also responsible for a particularly unsafe word form of prostate gland cancer, research have confirmed.

A University of Toronto squad establish prostate gland malignant neoplastic disease patients carrying the BRCA2 factor lived on norm for four old age after diagnosis.

The norm endurance clip for a adult male with prostate gland malignant neoplastic disease is 12 years.

Experts said the British Diary of Cancer survey emphasised the importance of early sensing and treatment.

It is of import that more than research is done in this country to guarantee that this grouping is targeted effectively

Dr Lesley WalkerCancer Research UK

Each twelvemonth around 35,000 new lawsuits of prostate gland malignant neoplastic disease are diagnosed in the UK, and around 10,000 work force decease from the disease

The up-to-the-minute survey - based on 301 patients - examined two closely related faulty genes, BRCA1 and BRCA2, both of which greatly increase a woman's hazard of breast cancer, and are linked to ovarian cancer.

Both factors cut mean endurance modern times in work force with prostate gland malignant neoplastic disease who carried them - for work force carrying BRCA1 the norm endurance clip was eight old age after diagnosis.

BRCA2 have already been linked to deathly prostate gland gland cancer, with an Icelandic survey recording an norm endurance clip among prostate malignant neoplastic disease patients carrying the factor of just 2.1 years.

The up-to-the-minute survey looks to corroborate that link.

Double whammy

Around one in 500 work force transport the faulty BRCA2 gene. They can be five modern times more likely than work force in the general population to develop prostate gland cancer.

Lead research worker Dr Steven Narod said: "We cognize that carrying a faulty BRCA2 factor additions a man's hazard of getting prostate gland gland cancer, and our survey shows that it also impacts how long he will last a diagnosing of the disease."

Dr Lesley Walker, of the charity Cancer Research UK, said: "Although lone a very little per centum of work force with prostate malignant neoplastic disease will transport a faulty BRCA2 gene, they're much more than likely to decease from the disease.

"It is of import that more than than research is done in this country to guarantee that this grouping is targeted effectively so malignant neoplastic disease is picked up at an early phase and, more importantly, that they are given the most appropriate treatment.

"Men with a strong household history of prostate gland or breast malignant neoplastic disease can see their general practitioner for advice."

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